How Does Isotretinoin (Oratane/Roaccutane) Work for Acne Treatment?

Acne can be a frustrating and confidence-shaking condition, especially when traditional treatments like creams and antibiotics don’t seem to work. 

For moderate to severe acne, a medication called Isotretinoin, commonly known by its brand names Oratane or Roaccutane, is often recommended. 

But how does it work, and is it the right option for you? 

Let’s dive into everything you need to know about isotretinoin and its role in acne treatment.


What is Isotretinoin?

Commonly known as Oratane or Roaccutane, Isotretinoin is an oral retinoid (vitamin A related medication), a specialised acne medication that acts like an off-switch for acne. 

It belongs to a class of drugs known as retinoids, which are derived from vitamin A. While it’s incredibly effective, isotretinoin is typically reserved for cases where other treatments have failed, patients have scarring or their acne is affecting their self confidence. 

Isotretinoin is a specialist prescription medication that is proven to work effectively.


How Does Isotretinoin Work?

Isotretinoin targets the root causes of acne, offering a comprehensive solution. Here’s how it works:

Reduces Sebum Production

One of the main causes of acne is the overproduction of sebum, an oily substance produced by your skin. Excess sebum clogs pores and creates an ideal environment for acne-causing bacteria. Isotretinoin reduces sebum production, helping to keep your pores clear.

Shrinks Oil Glands

Alongside lowering sebum production, isotretinoin shrinks the size of your skin’s oil glands. This permanent reduction makes it less likely for acne to return after completing the treatment.

Reduces Inflammation

Severe acne often involves redness and swelling caused by inflammation. Isotretinoin has anti-inflammatory properties that help calm your skin and reduce the severity of breakouts.

Prevents Pore Blockage

Isotretinoin also normalises how your skin cells behave, preventing dead skin cells from sticking together and clogging pores. This helps to reduce the formation of new acne lesions.

Kills Acne-Causing Bacteria

By creating an environment that’s less hospitable to bacteria, isotretinoin indirectly reduces the presence of Cutibacterium acnes (the bacteria linked to acne).


How Long Does Isotretinoin Take to Work?

Patients typically see improvement in the first few months, with fewer new pimples and old ones fading. Some may see their skin worsen initially (known as purging), but it’s often mild and temporary.

For most patients, skin clears completely
 in  6-9 months. Conclusion of therapy is discussed from 12 months, provided skin has been clear for at least several consecutive months.

The duration of treatment varies, but a typical course lasts 12 months (give or take a few months) pending varied individual response.


Who Can Use Isotretinoin?

Isotretinoin is generally prescribed for individuals with:

  • Severe cystic acne

  • Acne that has caused scarring or is likely to cause scars

  • Acne that hasn’t improved after trying antibiotics or topical treatments

  • If acne is causing self confidence issues

It’s important to consult a dermatologist like at ACNE RX to determine whether isotretinoin is suitable for you. Some factors, such as pregnancy or unstable mental health concerns may make isotretinoin an unsuitable option for you.


What Are the Side Effects of Isotretinoin?

Like ALL medication, side effects can occur.

At ACNE RX, Isotretinoin Treatment is carefully managed by a specialist to minimise any side effects.

We have included a list of side effects on our Isotretinoin information page here.


Take the Next Step Towards Clear Skin

Dealing with acne can be exhausting, but you don’t have to face it alone. Isotretinoin might be the answer you’ve been looking for, and with the right guidance, clear skin is possible. 

If you’re ready to explore your treatment options, ACNE RX is here to help. Reach out today to schedule a consultation and take the first step towards healthier, happier skin.

Mitch Hills

Entrepreneur, marketer and problem solver from Brisbane, Australia. 

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Understanding Acne: What Causes It and How to Treat It Effectively

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What Causes Acne? A Dermatologist’s Guide to Understanding Breakouts